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Diisopropylethylamine Trihydrofluoride
|
Catalog |
BCF-002 |
|
Product Name |
Diisopropylethylamine trihydrofluoride |
|
CAS |
131600-43-6 |
|
Molecular Formula |
C8H22NF3 |
|
Molecular Weight |
189.27 |
|
Appearance |
Colorless or light brown liquid |
|
Assay |
≥99.0% |
|
Water |
≤0.30% |
|
Boiling Point |
93-95℃ |
|
Flash Point |
113℃ |
|
Density |
0.965 g/mL at 25℃ |
|
Molecular structure |
|
Introduction
- Product Name: Diisopropylethylamine Trihydrofluoride (DIPEA·3HF)
- CAS No.: 131600-43-6
Applications
Fluorination & Deprotection
Mild and selective fluorinating agent for alcohol fluorination, hydrofluorination of alkenes, or cleavage of silyl protecting groups (e.g., TBS, TBDMS), ideal for acid-sensitive substrates (e.g., carbohydrates, nucleotides).
Superior selectivity over TEA·3HF due to steric hindrance from the bulky amine.
Pharmaceutical Synthesis
Key in synthesizing fluorinated drug intermediates (e.g., antiviral agents, PET tracers) and chiral fluorinated compounds.
Materials Chemistry
Enables fluorinated functional polymers (e.g., fluoropolymers, ionic liquids) for electronic material surface modification.
Storage Guidelines
Conditions
Store in a tightly sealed, light-protected container under inert gas (e.g., argon) at **-20°C to 4°C** with ≤20% relative humidity.
Stability
Moisture-sensitive; use PTFE/HDPE containers to prevent HF release.
Safety
Equip storage area with HF leak emergency kits; handle with full PPE.
Key Technical Properties
High Selectivity
Bulky amine structure minimizes nonspecific reactions, ideal for multifunctional molecules (e.g., natural product derivatives).
Low Corrosivity
Liquid form reduces equipment corrosion risks.
Broad Compatibility
Soluble in THF, acetonitrile; compatible with anhydrous or trace-water systems.
Why Choose Us
- Batch-specific certificates of analysis (COA) provided.
- Customizable packaging and technical support.
- Globally compliant with REACH, ISO 9001, and GMP guidelines.
Feel free to consult us at any time for a quotation.
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