Bis(2,6-diisopropylphenyl)carbodiimide

A high-efficiency coupling reagent that activates carboxylic acids to form reactive O-acylisourea intermediates, enabling efficient amide bond formation in SPPS/solution-phase synthesis.

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Product Introduction

Catalog	BCM-011
Product Name	Bis(2,6-diisopropylphenyl)carbodiimide
CAS	2162-74-5
EINECS	218-487-5
Molecular Formula	C₂₅H₃₄N₂
Molecular Weight	362.55
Appearance	White or yellowish crystalline powder
Assay	≥98.0%
Water	≤0.50%
Melting Point	48-51℃
Molecular structure

Introduction

Product Name: Bis(2,6-diisopropylphenyl)carbodiimide
CAS No.: 2162-74-5
Synonyms: DIC

Applications

Peptide Synthesis

A high-efficiency coupling reagent that activates carboxylic acids to form reactive O-acylisourea intermediates, enabling efficient amide bond formation in SPPS/solution-phase synthesis.

Minimizes racemization when paired with HOAt/Oxyma.

Pharmaceutical Intermediates

Critical in synthesizing antibiotics, antiviral agents, and small-molecule kinase inhibitors.

Organic Synthesis

Facilitates esterification, thioesterification, and C-N coupling in anhydrous or polar solvents (e.g., THF, DMF).